BioSB HotTopics: ONT Nanopore sequencing

On April 20, 2017 we are organising the first edition of the new series of HotTopics meetings that were previously organised by the Netherlands Bioinformatics Centre. BioSB HotTopics: ONT Nanopore sequencing April 20, 2017, TU Delft Nanopore sequencing has been revolutionizing the sequencing arena for the last few years. The last decade, sequencing went from…

HotTopics: revolution in virus discovery needed

The first HotTopics meeting organized under the flag of the brand new BioSB research school took place on January 13th 2014, with the topic “Virus Discovery and Beyond”. The afternoon featured four presentations that covering the latest developments in virus classification (Gorbalenya), virus discovery by metagenomics (Schürch), interpretation of viral sequences (Dutilh) and the involvement…

HotTopics: Virus discovery and beyond

January 13, 2014, Hogeschool Domstad Utrecht Historically, our perception and definition of viruses has evolved with the development of novel technologies. Presently, the genomic era defines the viral universe by characterizing genotypes at an ever accelerating pace, but often with no associated phenotype and/or physical entity. State of the art taxonomic classification recognizes only several…

HotTopics: Bioinformatics challenges for Synthetic Biology

October 15, 2012, SURF Utrecht Synthetic Biology is: (i) the design and construction of new biological parts, devices, and systems, and (ii) the re-design of existing, natural biological systems for useful purposes. It is also applying engineering to biology. This means it applies the ‘design – build – test’ engineering cycle to work on existing…

HotTopics: Detecting variations in the human genome using NGS

April 16, 2012, SURF Utrecht The new sequencing technologies are transforming the study of genomic variation. Detection of base-pair level and structural variants (SVs) and their association to human disease is a challenging and although various computational methods have been described for the detection of variations, no algorithm is fully capable of discovering all types…

HotTopics: Peptide and protein quantification using Mass Spectrometry

March 5, 2012, SURF Utrecht To date in addition to protein identification, quantification of abundances of proteins and peptides is common practice. In general there are stable isotope labeling, label-free and MSn approaches to obtain abundance levels of proteins using mass spectrometry. Each technique has its pro’s and con’s with differences in applicability and computational…

HotTopics: Multi-level omics integration

October 24, 2011, SURF Utrecht With the advancement of microarray and sequencing technology, many genomics researchers apply more than one profiling method for detection of molecular changes related to their phenotype of interest, e.g. cancer and complex diseases. To gain biological insight from these data, molecular phenotypes such as gene or protein expression are related…