NBIC Research School for Bioinformatics and Computational Biology

Activities to set up the NBIC Research PhD School for Bioinformatics and Computational Biology are gaining momentum. The NBIC Research School aims to offer a vibrant national environment for the scientific development and education of integrative bioinformatics and computational (systems) biology. The research school should sustain and foster the close research community that NBIC has…

HotTopics: Bioinformatics challenges for Synthetic Biology

October 15, 2012, SURF Utrecht Synthetic Biology is: (i) the design and construction of new biological parts, devices, and systems, and (ii) the re-design of existing, natural biological systems for useful purposes. It is also applying engineering to biology. This means it applies the ‘design – build – test’ engineering cycle to work on existing…

HotTopics: Detecting variations in the human genome using NGS

April 16, 2012, SURF Utrecht The new sequencing technologies are transforming the study of genomic variation. Detection of base-pair level and structural variants (SVs) and their association to human disease is a challenging and although various computational methods have been described for the detection of variations, no algorithm is fully capable of discovering all types…

HotTopics: Peptide and protein quantification using Mass Spectrometry

March 5, 2012, SURF Utrecht To date in addition to protein identification, quantification of abundances of proteins and peptides is common practice. In general there are stable isotope labeling, label-free and MSn approaches to obtain abundance levels of proteins using mass spectrometry. Each technique has its pro’s and con’s with differences in applicability and computational…

HotTopics: Multi-level omics integration

October 24, 2011, SURF Utrecht With the advancement of microarray and sequencing technology, many genomics researchers apply more than one profiling method for detection of molecular changes related to their phenotype of interest, e.g. cancer and complex diseases. To gain biological insight from these data, molecular phenotypes such as gene or protein expression are related…